In the 1930s Vladimir met Rudolph Kunett, a Russian who had emigrated to America in 1920. The Kunett family had been a supplier of spirits to Smirnoff in Moscow before the Revolution. In 1933 Vladimir sold Kunett the right to begin producing Smirnoff vodka in North America. However, the business in America was not as successful as Kunett had hoped. In 1938 Kunett couldn't afford to pay for the necessary sales licenses, and contacted John Martin, president of Heublein, who agreed to buy the rights to Smirnoff. Thanks to the introduction of vodka cocktails and successful advertisement campaigns, Smirnoff increased in popularity both in the US and internationally.

Since the 1990s….
During the 1990s one of Piotr Smirnov's descendants started producing Smirnov ( Смирновъ in Ukraine) vodka in Ukraine, claiming to be "The Only Real Smirnov". After a number of lawsuits Smirnoff successfully claimed back the trademark, whilst in 2006 Diageo tied up a joint venture deal with the Смирновъ company.

The Smirnoff company has the naming rights to the Smirnoff Music Centre, a concert amphitheatre in Dallas, Texas. They also sponsor the Smirnoff Underbelly, a major venue at the Edinburgh Fringe.

In the late 1990s Smirnoff introduced a series of new products onto the UK and later the European and North American market, which quickly became popular among young people, especially within the club scene (See "Alcopops"). There are two different products by the name of Smirnoff Ice. One, sold in the United States and France, is a citrus-flavoured malt beverage (5% ABV) sold in 'Original,' and 'Triple Black.' The other, sold in Europe (excluding France), Latin America, Australia and Canada, is a premixed vodka drink (4.7% (7% for the 'Double Black' variety in Canada and Australia)o ABV).

In recent years, Smirnoff has launched many other malt beverage lines. Smirnoff Ice Twisted was a spin-off of the American Smirnoff Ice that featured flavors such as Mandarin Orange and Green Apple. Confusion in branding between Smirnoff Twist Vodka and Smirnoff Twisted Malt Beverage resulted in the decision to drop the "Twisted" from the flavored line of Smirnoff Ice. Current flavors include Watermelon, Wild Grape, Pomegranate Fusion, Arctic Berry (Blueberry), Green Apple Bite and Raspberry Burst.

The next line of Smirnoff's malt beverages to hit shelves was their "Raw Teas" in flavors like Peach and Raspberry. This product line has been marketed most notably with the "Tea Partay" music video and website. It is similar to the brand Twisted Tea.

The newest product from Smirnoff is Smirnoff Source, an ultra-premium beer-alternative created with alcohol and spring water released in May of 2007. It is citrus flavored and lightly carbonated with 3.5% ABV.

A line of fruit flavoured vodkas with the "Twist" moniker appended on the end of the name have also been introduced. Flavors include Green Apple, Orange, Cranberry, Raspberry, Citrus (Lemon), Vanilla, Strawberry, Black Cherry, Watermelon, Lime, and, most recently, Blueberry.

Smirnoff trialed in the UK and Canada during 2004 a new blend of vodka entitled Smirnoff Penka. Marketing and distribution was handled by The Reserve Brands of Diageo plc. As of 2007 Penka continues to be available in the UK